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#1 16-04-2016 10:57:07

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Recherche / Nutrition, alimentation (divers)

Targedys
http://www.widoobiz.com/a-la-une/targed … 8-me/69426

« Au-delà d’une simple modification du microbiome comme pourrait le faire un probiotique usuel, nous proposons la mobilisation d’une nouvelle classe d’actifs thérapeutiques naturels »


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#2 14-12-2016 12:24:47

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Re : Recherche / Nutrition, alimentation (divers)

How to Win an Argument About Nutrition
https://authoritynutrition.com/how-to-w … ritionist/


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#3 01-04-2017 21:23:01

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Re : Recherche / Nutrition, alimentation (divers)

A quantum theory for the irreplaceable role of docosahexaenoic acid in neural cell signalling throughout evolution.
Crawford MA1, Broadhurst CL, Guest M, Nagar A, Wang Y, Ghebremeskel K, Schmidt WF. 2013
https://www.ncbi.nlm.nih.gov/pubmed/23206328

Des calculateurs quantiques dans le cerveau ?
http://www.futura-sciences.com/sciences … eau-51709/


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#4 10-05-2017 17:21:46

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Re : Recherche / Nutrition, alimentation (divers)

L'évolution humaine a été accélérée par... l'alcool
https://www.sciencesetavenir.fr/archeo- … ool_112696


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#5 02-06-2017 10:10:50

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Re : Recherche / Nutrition, alimentation (divers)

Sugary beverage intake and preclinical Alzheimer's disease in the community
http://www.alzheimersanddementia.com/ar … X/fulltext


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#6 06-06-2017 10:02:49

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Re : Recherche / Nutrition, alimentation (divers)

Hormones femelles dans les produits laitiers :
Hormones in Dairy Foods and Their Impact on Public Health - A Narrative Review Article
Hassan MALEKINEJAD and Aysa REZABAKHSH, 2015
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524299/


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#7 09-06-2017 12:05:13

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Re : Recherche / Nutrition, alimentation (divers)

Un article sur le végétalisme, des commentaires évoquent le paléolithique.
http://next.liberation.fr/livres/2017/0 … ge_1575045


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#8 03-10-2017 13:59:27

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Re : Recherche / Nutrition, alimentation (divers)

East African hunter-gatherer research suggests the human microbiome is an ecological disaster zone
https://theconversation.com/east-africa … zone-73668

En français
http://partage-le.com/2017/03/le-microb … ueilleurs/


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#9 26-10-2017 14:27:43

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Ce que les chasseurs-cueilleurs nous apprennent sur le mode de vie optimal
https://www.lanutrition.fr/les-news/ce- … ie-optimal

Les hommes préhistoriques souffraient-ils de cancers, maladies cardiovasculaires, diabète ?
http://www.thierrysouccar.com/blog/les- … es-diabete

"Les hommes préhistoriques ne dépassaient pas l'âge de 30 ans." Vrai ou Faux ?
http://www.thierrysouccar.com/blog/les- … ai-ou-faux


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#10 27-10-2017 07:48:40

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Re : Recherche / Nutrition, alimentation (divers)

Grand gibier et extinctions, thread de Will :
https://twitter.com/Evolving_Moloch/sta … 9256830976


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#11 21-11-2017 09:47:59

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Thread de Will sur espérance de vie et nutrition HG, et biais anthropologiques.

https://twitter.com/Evolving_Moloch/sta … 2966127617


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#12 30-11-2017 14:53:03

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Re : Recherche / Nutrition, alimentation (divers)

Of Evolution, Culture, and the Obstetrical Dilemma
https://undark.org/article/obstetrical- … hildbirth/

Alimentation et accouchement.


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#13 02-05-2018 16:15:09

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Re : Recherche / Nutrition, alimentation (divers)

A Look at the Disputed Science on Salt: Is Lower Always Better?
https://www.nutritioncoalition.us/salt- … ays-better

Below is the scientific evidence questioning/contradicting recommendations that a “lower is better” recommendation on sodium is advisable for the general population.

At least five separate scientific teams published in major peer-reviewed journals, in addition to a 2013 review by the U.S. Institute of Medicine (National Academy of Sciences) all concluded that lowering salt below a moderate amount increased the risk of disease and death

The policy of “lower-is-better” is therefore clearly not evidence-based.

Population-wide policies must be backed by strong and consistent scientific evidence. That is not the case with salt.
Evidence on Salt
The following is a list of the evidence contradicting the current dietary recommendations that “lower is better’ for salt intake, followed by specific evidence looking at salt intake in type 2 diabetes, as well as further commentary pieces from various sources.

1. Sodium Intake in Populations: Assessment of Evidence. Institute of Medicine, National Academy of Sciences (2013)

“The committee also concludes that studies on health outcomes are inconsistent in quality and insufficient in quantity to determine that sodium intakes below 2,300 mg/ day either increase or decrease the risk of heart disease, stroke, or all-cause mortality in the general U.S. population.”

The report concludes that sodium intake below 2,300 mg/day may lead to adverse health outcomes in several “disease-specific populations,” including those with diabetes and pre-existing heart disease, a population that includes tens of millions of Americans.

2. Fatal and nonfatal outcomes, incidence of hypertension, and blood pressure changes in relation to urinary sodium excretion. Journal of the American Medical Association (2011). K. Stolarz-Skrzypek, T. Kuznetsova, L. Thijs, et al; European Project on Genes in Hypertension (EPOGH) Investigators.

“In this population-based cohort, systolic blood pressure, but not diastolic pressure, changes over time aligned with change in sodium excretion, but this association did not translate into a higher risk of hypertension or CVD complications. Lower sodium excretion was associated with higher CVD mortality…. Taken together, our current findings refute the estimates of computer models of lives saved and health care costs reduced with lower salt intake. They do also not support the current recommendations of a generalized and indiscriminate reduction of salt intake at the population level. However, they do not negate the blood pressure−lowering effects of a dietary salt reduction in hypertensive patients”

3. Compared with usual sodium intake, low- and excessive-sodium diets are associated with increased mortality: a meta-analysis. Journal of Hypertension (2014). N. Graudal, G. Jürgens, B. Baslund, M.H. Alderman.

“Our study extends the IOM report by identifying a specific range of sodium intake (2,645–4,945 mg) associated with the most favorable health outcomes, within which variation in sodium intake is not associated with variation in mortality.”

“Both low sodium intakes and high sodium intakes are associated with increased mortality, consistent with a U-shaped association between sodium intake and health outcomes.”

4. Urinary sodium and potassium excretion, mortality, and cardiovascular events. New England Journal of Medicine (2014). M. O'Donnell, McMaster University, A. Mente, S. Rangarajan, et al, for the PURE investigators.

“In this study in which sodium intake was estimated on the basis of measured urinary excretion, an estimated sodium intake between 3 g per day and 6 g per day was associated with a lower risk of death and cardiovascular events than was either a higher or lower estimated level of intake. As compared with an estimated potassium excretion that was less than 1.50 g per day, higher potassium excretion was associated with a lower risk of death and cardiovascular events.

Updated Findings: Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies. The Lancet (2016). A. Mente, Department of Clinical Epidemiology and Biostatistics, McMaster University, M. O’Donnell, S. Rangarajan, et al, for the PURE, EPIDREAM, and ONTARGET / TRANSCEND Investigators.

“Compared with moderate sodium intake, high sodium intake is associated with an increased risk of cardiovascular events and death in hypertensive populations (no association in normotensive population), while the association of low sodium intake with increased risk of cardiovascular events and death is observed in those with or without hypertension. These data suggest that lowering sodium intake is best targeted at populations with hypertension who consume high sodium diets.”

5. The technical report on sodium intake and cardiovascular disease in low- and middle-income countries by the joint working group of the World Heart Federation, the European Society of Hypertension and the European Public Health Association. European Heart Journal (2017). G. Mancia, University of Milano-Biccoca,  S. Oparil  P.K. Whelton, et al.

“Prospective cohort studies have identified the optimal range of sodium intake to reside in the moderate range (3–5 g/day), where the risk of cardiovascular disease and death is lowest. Therefore, there is consistent evidence from clinical trials and observational studies to support reducing sodium intake to less than 5 g/day in populations, but inconsistent evidence for further reductions below a moderate intake range (3–5 g/day).”

Quote from paper: “Sodium is an essential nutrient. This implies that there must be a ‘U’-shaped relationship between dietary sodium intake and cardiovascular events, but there is no consensus of where the minimum risks lies.”

6. Association Between Sodium Excretion and Cardiovascular Disease and Mortality in the Elderly: A Cohort Study. The Journal of Post-Acute and Long-term Care Medicine (2018) Diana Lelli, MD, Raffaele Antonelli-Incalzi, MD, Stefania Bandinelli, MD, Luigi Ferrucci, MD, PhD, Claudio Pedone, MD, PhD, MPH

Conclusion: "Reduced sodium excretion is associated with increased mortality in a sample of community-dwelling older people, especially among the frail participants. High levels of sodium excretion are not associated with adverse outcomes in this population; therefore, sodium restriction might not be beneficial in older people."
Associated Commentary

Editorial by The New England Journal of Medicine (2014), commenting on evidence to date

“In the absence of such a [randomized, controlled clinical] trial, the results argue against reduction of dietary sodium as an isolated public health recommendation.”

Editorial by The Lancet - Salt—too much or too little? (2016)

“There is no argument other than “excessive salt in the diet raises blood pressure”, and that strategies to reduce salt in individuals with hypertension prevent the cardiovascular consequences of the disease. However, the corollary that reducing sodium intake across populations will be beneficial to all, has been challenged with the assertion that doing so might indeed be harmful.”

International Experts Call Salt Guidelines Far Too Restrictive. Cardiobrief (2017), Larry Husten

Type 2 Diabetes
In patients with type 2 diabetes, two studies have observed increased all-cause and cardiovascular mortality associated with low-sodium intake.

1. Dietary Salt Intake and Mortality in Patients With Type 2 Diabetes. Diabetes Care (2011). E.I. Ekinci, S. Clarke, M.C. Thomas, et al.

“In patients with type 2 diabetes, lower 24-h urinary sodium excretion was paradoxically associated with increased all-cause and cardiovascular mortality.”

2. Urinary Sodium Concentration Is an Independent Predictor of All-Cause and Cardiovascular Mortality in a Type 2 Diabetes Cohort Population. Journal of Diabetes Research, 2017. P-J. Saulnier, CHU de Poitiers, Centre d’Investigation Clinique, Université de Poitiers, UFR Médecine Pharmacie, Inserm, Poitiers, E. Gand, S. Ragot et al, and SURDIAGENE Study group.

“Urinary sodium independently predicted all-cause and cardiovascular mortality. An increase of one standard deviation of urinary sodium was associated with a decrease of 21% of all-cause mortality and 22% of cardiovascular mortality.”
Additional commentary on the salt debate

Congressman Andy Harris, MD, sends a letter (June 30, 2016) to FDA Commissioner Robert Califf to express “strong disappointment and objection” to the FDA’s new voluntary sodium limits in food. Harris asks the Commissioner to explain misrepresentation of the IOM 2013 study on sodium.

Could 95 Percent of the World’s People Be Wrong About Salt? Washington Post (2015), Peter Whoriskey, staff writer.

The Salt Libel - Wall Street Journal (2014)

The Population Risks of Dietary Salt Excess are Exaggerated. The Canadian Journal of Cardiology (2014). A. Mente, Population Health Research Institute, McMaster University, M.J. O’Donnell, S. Yusuf.

“Policy positions on salt consumption (based largely on the association of sodium and blood pressure [BP]) has remained unchanged since the 1970s, until recently. However, this is beginning to change as new evidence emerges. The evidence supports a strong association of sodium with BP and cardiovascular disease events in hypertensive individuals, the elderly, and those who consume > 6 g/d of sodium. However, there is no association of sodium with clinical events at 3 to 6 g/day and a paradoxical higher rate of events at < 3 g/day. Therefore, until new evidence emerges, the optimal range of sodium consumption should be considered to be between 3 and 6 g/d. Population-wide sodium reduction is not justified in countries such as Canada.”


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#14 02-05-2018 18:04:18

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Re : Recherche / Nutrition, alimentation (divers)

February 20, 2018
Effect of Low-Fat vs Low-Carbohydrate Diet on 12-Month Weight Loss in Overweight Adults and the Association With Genotype Pattern or Insulin SecretionThe DIETFITS Randomized Clinical Trial
Christopher D. Gardner, PhD1; John F. Trepanowski, PhD1; Liana C. Del Gobbo, PhD1; et al
https://jamanetwork.com/journals/jama/a … ct/2673150

Etude complète : https://www.gwern.net/docs/longevity/2018-gardner.pdf

Results  Among 609 participants randomized (mean age, 40 [SD, 7] years; 57% women; mean body mass index, 33 [SD, 3]; 244 [40%] had a low-fat genotype; 180 [30%] had a low-carbohydrate genotype; mean baseline INS-30, 93 μIU/mL), 481 (79%) completed the trial. In the HLF vs HLC diets, respectively, the mean 12-month macronutrient distributions were 48% vs 30% for carbohydrates, 29% vs 45% for fat, and 21% vs 23% for protein. Weight change at 12 months was −5.3 kg for the HLF diet vs −6.0 kg for the HLC diet (mean between-group difference, 0.7 kg [95% CI, −0.2 to 1.6 kg]). There was no significant diet-genotype pattern interaction (P = .20) or diet-insulin secretion (INS-30) interaction (P = .47) with 12-month weight loss. There were 18 adverse events or serious adverse events that were evenly distributed across the 2 diet groups.

Conclusions and Relevance  In this 12-month weight loss diet study, there was no significant difference in weight change between a healthy low-fat diet vs a healthy low-carbohydrate diet, and neither genotype pattern nor baseline insulin secretion was associated with the dietary effects on weight loss. In the context of these 2 common weight loss diet approaches, neither of the 2 hypothesized predisposing factors was helpful in identifying which diet was better for whom.


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#15 03-05-2018 08:19:53

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Re : Recherche / Nutrition, alimentation (divers)

Une grosse discussion sur alimentation, cancer, boisson et potentiels bulshits :


Vinay Prasad
@VinayPrasadMD
8 hil y a 8 heures

A couple weeks ago I said these HARSH words about a recent Lancet study & the media coverage where the authors argued more than 5-7 drinks a wk (100g/wk) was too many
I took heat
Well, I meant it then, and I mean it now.
And here is the TWEETORIAL on this paper/ nutritional epi

https://twitter.com/VinayPrasadMD/statu … 0307522560

Db5zzpTUQAAekJx.jpg


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#16 12-05-2018 17:22:23

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Re : Recherche / Nutrition, alimentation (divers)

Grosse synthèse sur le jeûne thérapeutique :
Jeûne, régimes restrictifs et cancer : revue systématique des données scientifiques et analyse socio-anthropologique sur la place du jeûne en France
https://www6.inra.fr/nacre/Le-reseau-NA … ancer-2017

jec3bbne.png


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#17 09-09-2018 14:42:22

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Re : Recherche / Nutrition, alimentation (divers)

Sur le jeûne et ses possibles voies d'action.

Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota
Guolin Li, Cen Xie, Siyu Lu, Oksana Gavrilova, Andrew D. Patterson, Frank J. Gonzalez
September 14, 2017
https://www.cell.com/cell-metabolism/fu … 17)30504-1

Daily Fasting Improves Health and Survival in Male Mice Independent of Diet Composition and Calories
Sarah J. Mitchell, Michel Bernier, Julie A. Mattison, Miguel A. Aon, Tamzin A. Kaiser, R. Michael Anson, Yuji Ikeno, Rozalyn M. Anderson, Donald K. Ingram, Rafael de Cabo
September 06, 2018
https://www.cell.com/cell-metabolism/fu … 18)30512-6

Asprosin, a Fasting-Induced Glucogenic Protein Hormone
Chase Romere, Clemens Duerrschmid, Juan Bournat, Nancy F. Butte, David D. Moore, Atul R. Chopra
April 14, 2016
https://www.cell.com/cell/fulltext/S009 … 16)30213-6


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#18 08-10-2018 21:21:22

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Re : Recherche / Nutrition, alimentation (divers)

Why You Should Be Skeptical of the Latest Nutrition Headlines: Part 1
on September 27, 2018 by Chris Kresser
https://chriskresser.com/why-you-should … paign=blog


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#19 14-11-2018 22:05:28

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Re : Recherche / Nutrition, alimentation (divers)

Okinawa
Beyond Merroir: The Okinawan Taste for Clams
C. Anne Claus
http://gcfs.ucpress.edu/content/17/3/49

History and characteristics of Okinawan longevity food
Director Hiroko Sho
28 June 2008
https://onlinelibrary.wiley.com/doi/abs … 01.00235.x

Okinawan food culture in the Ryukyu island is one of the world’s most interesting culture because its consumers have the longest life expectancies and low disability rates. It is a product of cultural synthesis, with a core of Chinese food culture, inputs through food trade with South‐East Asia and the Pacific and strong Japanese influences in eating style and presentation. The Satsamu sweet potato provides the largest part of the energy intake (and contributes to self‐sufficiency), there is a wide array of plant foods including seaweed (especially konbu) and soy, and of herbaceous plants, accompanied by fish and pork, and by green tea and kohencha tea. Infusing multiple foodstuff and drinking the broth is characteristic. Raw sugar is eaten. The concept that ‘food is medicine’ and a high regard accorded medical practice are also intrinsic of Okinawan culture. Again, food‐centered and ancestral festivities keeep the health dimensions well‐developed. Pork, konbu and tofu (soy bean‐curd) are indispensable ingredients in festival menus, and the combination of tofu and seaweed are used everyday. Okinawan food culture is intimately linked with an enduring belief of the system and highly developed social structure and network.

https://www.google.com/search?q=cochon+ … Q_1VAqcZ9M

IKARIA
Ikarian Food - Healthy Diet
http://www.island-ikaria.com/about-ikar … -Food-Diet

They still base much of their diet on wild greens, beans, fruits and vegetables picked in season, fish just plucked from the sea, pigs raised in the backyard, goats that graze wild in the mountains, and chickens that also eat leftovers from family meals. Family and locally produced olive oil, honey, wine, goat’s milk and cheese and mountain teas are all used and consumed in abundance. Many people still forage for wild foods, from nutritionally dense edible greens and weeds, berries and herbs to mushrooms. Ikarians are also experienced fisherman both professional and amateur, with families often catching on their own the seafood they consume.
Because Ikarians traditionally do not eat significant amounts of meat, they consume above average quantities of fish, vegetables, beans and pulses, many of which are grown locally.

True Blue Zones: Ikaria, Greece
http://nourishingtraditions.com/true-bl … ia-greece/

This description is similar to descriptions applied to other blue zones: Sardinia, Okinawa and Costa Rica.  But as we have seen, the common factor in all these diets is generous consumption of lard and pork, and higher consumption of animal foods among those who reach great old age. And as with our other three examples, Buettner’s descriptions of the meals he eats and the foods consumed are inconsistent with his low-fat conclusions.

For example, goat milk. Inconvenient fact: goat milk is a dairy food. The Ikarians consume a lot of goat milk and goat milk products, such as cheese and yogurt. This is not a diet that is low in dairy foods; it is a diet where dairy foods are consumed with almost every meal.  And goat milk is higher in fat and higher in saturated fat than cows milk. And remember this is raw goat milk (Buettner never mentions the R word), with all its nutritional components intact—nature’s perfect food, especially for the elderly.

True Blue Zones: Sardinia
http://nourishingtraditions.com/true-bl … -sardinia/


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#20 19-11-2018 10:44:35

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Re : Recherche / Nutrition, alimentation (divers)

L’évolution de la longévité à Okinawa, 1921-2000
Michel Poulain and Kusuto Naito, 2004

https://www.erudit.org/en/journals/cqd/ … /010851ar/


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#21 17-12-2018 19:12:38

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Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18 countries from five continents (PURE): a prospective cohort study
https://www.sciencedirect.com/science/a … 3617322523


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